Daniel Segelcke

Curriculum Vitae

Daniel Segelcke graduated at the Ruhr University of Bochum, where he received extensive training in behavioral biology and animal pain models for migraine. Following his PhD in 2012, he joined the laboratories of Esther Pogatzki-Zahn (EPZ) at the University of Münster to investigate behavioral, cerebral processing and proteome signatures in animal models for post-surgical, pathogene pain, neuropathic pain, and bone-tumor induced pain. He successfully established novel rodent behavior assays, devices and analytic methods to investigate multidimensional pain modalities in rats and mice in longitudinal studies. Machine learning approaches performs some of these analysis methods. During his time at the University of Münster, he raised peer-reviewed funding for a preclinical systematic review, which investigate the impact of buprenorphine (opioid) in biomedical animal research. During his time at the University of Münster, he raised peer-reviewed funding for a preclinical systematic review, which investigate the impact of buprenorphine (opioid) in biomedical animal research.

(Daniel Segelcke (0000-0002-4405-2596) (orcid.org)

Google Scholar: H-index: 11, 592 citations,

Scopus: H-index: 10, 351 citations

Selected literature

Segelcke D, van der Burgt M, Kappert C, Schmidt Garcia D, Sondermann JR, Bigalke S, Pradier B, Gomez-Varela D, Zahn PK, Schmidt M, Pogatzki-Zahn EM. Phenotype- and species-specific skin proteomic signatures for incision-induced pain in humans and mice. Br J Anaesth 2023;130(3):331–42. 10.1016/j.bja.2022.10.040.

Segelcke D, Linnemann J, Pradier B, Kronenberg D, Stange R, Richter H, Goerlich D, Baldini N, Di Pompo G, Verri WA, Avent S, Pogatzki-Zahn EM. Behavioral voluntary and social bioassays enabling identification of complex and sex dependent pain- (-related) phenotypes in rats with bone cancer 2022. 10.1101/2022.11.19.517016.

Segelcke D, Talbot SR, Palme R, La Porta C, Pogatzki-Zahn E, Bleich A, Tappe-Theodor A. Experimenter familiarization is a crucial prerequisite for assessing behavioral outcomes and reduces stress in mice not only under chronic pain conditions. Sci Rep 2023;13(1):2289. 10.1038/s41598-023-29052-7.

Tappe-Theodor A, Pitzer C, Lewejohann L, Jirkof P, Siegeler K, Segelcke A, Drude N, Pradier B, Pogatzki-Zahn E, Hollinderbäumer B, Segelcke D. The "WWHow" Concept for Prospective Categorization of Post-operative Severity Assessment in Mice and Rats. Frontiers in veterinary science 2022;9:841431. 10.3389/fvets.2022.841431.

Segelcke D, Fischer HK, Hütte M, Dennerlein S, Benseler F, Brose N, Pogatzki-Zahn EM, Schmidt M. Tmem160 contributes to the establishment of discrete nerve injury-induced pain behaviors in male mice. Cell Reports 2021;37(12):110152. 10.1016/j.celrep.2021.110152.

Pogatzki-Zahn EM, Gomez-Varela D, Erdmann G, Kaschube K, Segelcke D, Schmidt M. A proteome signature for acute incisional pain in dorsal root ganglia of mice. Pain 2021;162(7):2070–86. 10.1097/j.pain.0000000000002207.